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These included hypoglycaemia frequency very common with the combination of sulphonylurea and metformin , influenza common with insulin with or without metformin , nausea and vomiting common with metformin , flatulence common with metformin or pioglitazone , constipation common with the combination of sulphonylurea and metformin , peripheral oedema common with pioglitazone or the combination of pioglitazone and metformin , somnolence and diarrhoea uncommon with metformin , and dry mouth uncommon with insulin with or without metformin .

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