These included hypoglycaemia frequency very common with the combination of sulphonylurea and metformin , influenza common with insulin with or without metformin , nausea and vomiting common with metformin , flatulence common with metformin or pioglitazone , constipation common with the combination of sulphonylurea and metformin , peripheral oedema common with pioglitazone or the combination of pioglitazone and metformin , somnolence and diarrhoea uncommon with metformin , and dry mouth uncommon with insulin with or without metformin .
And her2 specific comments in this 2011 meta-analysis of metformin s potential against cancer sound very positive in her2-positive breast cancer cell lines treated with metformin demonstrate a surge overexpression of apoptosis .
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Recent work has confirmed that biguanides such as metformin can exert cell autonomous, dose-dependent effects on tumor cell proliferation 12,39 .
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